home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
Shareware Overload Trio 2
/
Shareware Overload Trio Volume 2 (Chestnut CD-ROM).ISO
/
dir26
/
med9410o.zip
/
M94A2728.TXT
< prev
next >
Wrap
Text File
|
1994-10-25
|
2KB
|
38 lines
Document 2728
DOCN M94A2728
TI Prevalence of p24 antigen in a shock trauma population.
DT 9412
AU Constantine NT; Abesamis C; Bansal J; Preas MA; Caplan E; Department
Pathology, Univ. of Maryland Sch. of Med., Baltimore; 21201.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):238 (abstract no. PB0380). Unique
Identifier : AIDSLINE ICA10/94369847
AB OBJECTIVES: To determine the prevalence of HIV p24 antigen in a
population admitted to the Shock Trauma Center in Baltimore, MD, USA.
where the prevalence of infection is 3%. METHODS: 639 sequentially
collected sera were tested retrospectively for the presence of HIV p24
antigen. This population had previously been determined to have a
prevalence of HIV infection of 3% using antibody assays. All sera were
tested using the Coulter HIV-1 p24 antigen test as recommended by the
manufacturer. Reactive samples were further tested using the Coulter
HIV-1 p24 antigen neutralization procedure designed to confirm the
presence of p24 antigen. Criteria for positivity included a reduction in
OD of at least 50% as compared to a non-neutralized aliquot. RESULTS: 16
of the 639 sera were initially reactive by the p24 antigen assay; in
addition, 5 sera exhibited a grey-zone reactivity (within 20% of the
established cutoff). Of these 21 sera, only two (0.3%) met the
manufacturer's criteria for confirmed positivity for p24 antigen (were
significantly neutralized). Both of these samples had also been positive
for antibody to HIV. DISCUSSION AND CONCLUSIONS: Although 2 sera were
confirmed positive for p24 antigen, antibody had also been detected,
suggesting established rather than early infection. Antigen testing in
this population is unwarranted as an attempt to detect early infection.
DE Baltimore/EPIDEMIOLOGY Human HIV Antibodies/BLOOD HIV Core Protein
p24/*BLOOD HIV Seropositivity/DIAGNOSIS/*EPIDEMIOLOGY/IMMUNOLOGY *HIV
Seroprevalence HIV-1/*IMMUNOLOGY Shock/*IMMUNOLOGY Trauma
Centers/STATISTICS & NUMER DATA Wounds and Injuries/*IMMUNOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).